Brian Thrall
Expertise
Dr. Thrall's research focuses on understanding the mechanisms in which changes in the extracellular environment modulate cell signaling pathways to influence the balance between cell proliferation and cell death. Current research projects are employing genomic and proteomic strategies to investigate the molecular mechanisms of cross-regulation between growth factor and stress signaling pathways, using mammary epithelial cells and macrophages as model systems. Ultimately, the goal of these studies is to provide a better understanding of how information processing through divergent signaling pathways is coordinately regulated to maintain homeostasis, and why these homeostatic mechanisms break down during disease.
In addition to primary role as Technical Group Leader for the Cell Biology Group at PNNL, he holds adjunct positions in the Graduate Research Program at Washington State University and regularly serves as a peer reviewer for a variety of publications, including the Journal of Biology and Chemistry, Toxicology and Applied Pharmacology, Differentiation, Oncogene, and Toxicological Sciences. In addition, Dr. Thrall has served on several special emphasis review panels for the National Institutes of Health in the area of proteomic and genomic analysis of cancer, as well as a proposal reviewer for the Department of Energy, U.S. Air Force Office of Scientific Research and the Department of State. He has authored or co-authored over 50 peer-reviewed publications.
Education
- Ph.D., Pharmacology, Washington State University, 1990
- M.S., Biology, University of South Dakota, 1985
- B.S., Biology, University of South Dakota, 1983