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March 28th, 2008 - Publications and appointments.
February 15th, 2008 - Publications, programmatic awards, and presentations.
January 13th, 2008 - Leadership changes.
September 13th, 2007 - Center for Novel Biomarkers of Response at PNNL.
May 29th, 2007 - Highlighting staff presentations to foreign conferences.
May 10th, 2007 - Featuring news on upcoming staff presentations.
March 22nd, 2007 - Highlighting a publication in Emerging Infectious Diseases and participation in the 5th Annual American Society for Microbiology (ASM) Biodefense and Emerging Diseases Research Meeting.
March 13th, 2007 - Announcement highlighting staff participation in the Society of Toxicology Annual Meeting.
February 2007 - Update on staff publications.
Multiple grants awarded to EBI
September, 2007
- The NIH's National Institute of Environmental Health Sciences (NIEHS) has awarded PNNL $5.9M to establish the Center for Novel Biomarkers of Response at PNNL. This Center is part of the NIH-wide Genes and Environment Initiative. The U54 Center grant application was led by Joel Pounds, who will also direct the Center.
- Galya Orr received $200K through an EPA Star grant to investigate the Internalization and Fate of Individual Manufactured Nanomaterial within Living Cells.
- Brian Thrall received $1.9M from the NIH for a R01 grant entitled, Systems Analysis of Nanoparticle Biocompatibility. Several PNNL investigators from the Systems Toxicology of Nanomaterials Focus Area are participating in this research, including Jon Jacobs, Barb Tarasevich, Justin Teeguarden, Katrina Waters, Bobbie-Jo Webb-Robertson, and Rick Zangar.
Society of Toxicology's 45th Annual Meeting
Charlotte, NC, March 25-29, 2007
PNNL scientists make a strong showing at the Society of Toxicology's 45th Annual Meeting! SK Sundaram, Galya Orr, Paul Hinderliter, and Justin Teeguarden will each present research during the four day conference in North Carolina.
- "Current Developments in Real-time Fourier Transform Infrared Spectroscopic Analysis of the Cellular Reponse to Nanomaterials" presented by SK Sundaram as part of the Biomarkers of Effect session
- "Size and Surface Properties Determine the Internalization Pathway of Nanoparticles by Type II Alveolar Epithelial Cells" Presented by Galya Orr as part of the Nanoparticles session
- "Agglomeration State Affects In Vitro Nanoparticle Dosimetry and Toxicity Assessments" presented by Paul Hinderliter in the Computational Toxicology session.
- "Old Principles in a New Field: Particokinetics Affects Size and Time Dependent Toxicity of Nano Silica in Macrophages" delivered by Justin Teeguarden in the Disposition/Pharmacokinetics session
5th Annual American Society for Microbiology (ASM) Biodefense and Emerging Diseases Research Meeting
Follow link to download poster as a PDF file
The 5th Annual ASM meeting featured a poster submitted by PNNL scientist Dave Wunschel. The work illustrates the integration of tools under development within the Rapid Response to Biological Agents Focus Area to create host response signatures. Evidence of biosignatures of infection from both volatile organics and peptides were observed from small intestine cells cultured and infected with the 3D cell culture. These results give us confidence that useful biomarkers of biothreat agents can be identified in non-invasive samples such as breath and saliva.
Cambridge Healthtech Institute's Fourth Annual Protein Biomarkers 2006
Philadelphia, PA, November 15-16, 2006
Joel Pounds, Senior Staff Scientist in Cell Biology and Biochemistry and EBI focus area lead in Systems Toxicology of Nanomaterials, delivered an invited presentation on Plasma Protein Biomarker Discovery for COPD Progression Using FTICR-MS Accurate Mass and Time Tag.
Technology Today interviews Terri Stewart
Follow link to view streaming video clip
Environmental Biomarkers Lead Terri Stewart is interviewed by PNNL's Technology Today on the scope and goals of the initiative.
Ann Miracle appointed to editorial board of Environmental Toxicology and Chemistry
AAAS Annual Meeting
St. Louis, MO, February 16-20, 2006
PNNL scientist, S.K. Sundaram organized the symposium on "Toxicology of Nanoparticles" as part of the AAAS 2006 Nanotechnology Seminar. PNNL participants in this particular symposium included:
- Rick Corley, Virtual Respiratory Tract Model
- Tom Weber, Real-time Monitoring of PM-Lung Cell Interactions I: Biology and Spectroscopy
- S.K. Sundaram, Real-time Monitoring of PM-Lung Cell Interactions II: Functionalization and Cell Adhesion
Second International Symposium on Nanotechnology and Occupational Health
Minneapolis, MN, October 3-6, 2005
PNNL scientist, Justin Teeguarden presented, "A multi-disciplinary bio-computational approach for assessing the safety of inhaled nanoparticles."
CHI's Third Annual Protein Biomarkers 2005
Philadelphia, PA, September 26-28, 2005
PNNL scientist, Richard Zangar presented, "Biomarker Discovery and Validation Using Accurate Mass and Time Tag (AMT) Proteomics and ELISA Microarrays."
